April 24, 2024
Innovative chemistry yields potential antidepressant drugs

Innovative chemistry yields potential antidepressant drugs

  • RESEARCH BRIEFINGS
  • 28 September 2022

Computational simulation of interactions of each of 75 million molecules with a model structure of the 5-HT2A receptor, which mediates the actions of psychedelic drugs, identified molecules that selectively activate the receptor. When tested in mice, two of these compounds had antidepressant-like actions without the side effects of psychedelic drugs.

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