December 7, 2022

A proton-pumping enzyme in the brain switches between modes

  • RESEARCH BRIEFINGS
  • 23 November 2022

The enzyme V-ATPase pumps protons into vesicles at the synaptic connections between neuronal cells, and is crucial for neuronal communication. Observations of individual V-ATPase molecules reveal that they randomly switch between proton-pumping, rest and leaking modes, which each last for several minutes, with potential implications for neurotransmission.

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