May 26, 2024
Gut bacteria alleviate smoking-related NASH by degrading gut nicotine – Nature

Gut bacteria alleviate smoking-related NASH by degrading gut nicotine – Nature

  • Okamoto, M. et al. Cigarette smoking is a risk factor for the onset of fatty liver disease in nondrinkers: a longitudinal cohort study. PLoS ONE 13, e0195147 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ou, H., Fu, Y., Liao, W., Zheng, C. & Wu, X. Association between smoking and liver fibrosis among patients with nonalcoholic fatty liver disease. Can. J. Gastroenterol. Hepatol. 2019, 6028952 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jung, H. S. et al. Smoking and the risk of non-alcoholic fatty liver disease: a cohort study. Am. J. Gastroenterol. 114, 453–463 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Takenaka, H. et al. Non-alcoholic fatty liver disease is strongly associated with smoking status and is improved by smoking cessation in Japanese males: a retrospective study. Kobe J. Med. Sci. 66, E102–E112 (2020).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yuan, S. et al. Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study. Eur. J. Epidemiol. 37, 723–733 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • WHO Report on the Global Tobacco Epidemic 2008: The MPOWER Package 14 (WHO, 2008).

  • WHO Global Report on Trends in Prevalence of Tobacco Smoking 2000–2025, Second Edition 21 (WHO, 2018).

  • Holford, T. R. et al. Tobacco control and the reduction in smoking-related premature deaths in the United States, 1964-2012. JAMA 311, 164–171 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xue, S., Schlosburg, J. E. & Janda, K. D. A new strategy for smoking cessation: characterization of a bacterial enzyme for the degradation of nicotine. JACS 137, 10136–10139 (2015).

    Article 
    CAS 

    Google Scholar
     

  • Dulchavsky, M., Clark, C. T., Bardwell, J. C. A. & Stull, F. A cytochrome c is the natural electron acceptor for nicotine oxidoreductase. Nat. Chem. Biol. 17, 344–350 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tripathi, A. et al. The gut-liver axis and the intersection with the microbiome. Nat. Rev. Gastroenterol. Hepatol. 15, 397–411 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lindell, G. et al. Acute effects of smoking during modified sham feeding in duodenal ulcer patients. An analysis of nicotine, acid secretion, gastrin, catecholamines, epidermal growth factor, prostaglandin E2, and bile acids. Scand. J. Gastroenterol. 28, 487–494 (1993).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Han, X. J. et al. Stimulation of α7 nicotinic acetylcholine receptor by nicotine suppresses decidual M1 macrophage polarization against inflammation in lipopolysaccharide-induced preeclampsia-like mouse model. Front. Immunol. 12, 642071 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sousa, M. V. et al. Smoking accelerates renal cystic disease and worsens cardiac phenotype in Pkd1-deficient mice. Sci. Rep. 11, 14443 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu, X. X. et al. Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. Cell Death Dis. 9, 171 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fluhr, L. et al. Gut microbiota modulates weight gain in mice after discontinued smoke exposure. Nature 600, 713–719 (2021).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang, S. N., Liu, Z., Tang, H. Z., Meng, J. & Xu, P. Characterization of environmentally friendly nicotine degradation by Pseudomonas putida biotype A strain S16. Microbiology 153, 1556–1565 (2007).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tang, H. Z. et al. A novel gene, encoding 6-hydroxy-3-suceinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16. Appl. Environ. Microbiol. 74, 1567–1574 (2008).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang, C. et al. Nicotine accelerates atherosclerosis in apolipoprotein E-deficient mice by activating α7 nicotinic acetylcholine receptor on mast cells. Arterioscler. Thromb. Vasc. Biol. 37, 53–65 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • Liu, R., Kurose, T. & Matsukura, S. Oral nicotine administration decreases tumor necrosis factor-alpha expression in fat tissues in obese rats. Metabolism 50, 79–85 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wu, Y. et al. Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nat. Med. 21, 373–382 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Garcia, D. & Shaw, R. J. AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance. Mol. Cell 66, 789–800 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Marra, F. Lipotoxicity and the gut-liver axis in NASH pathogenesis. J. Hepatol. 68, 280–295 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xue, Y. et al. GPS 2.0, a tool to predict kinase-specific phosphorylation sites in hierarchy. Mol. Cell. Proteomics 7, 1598–1608 (2008).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Filosto, S., Ashfaq, M., Chung, S., Fry, W. & Goldkorn, T. Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines. J. Biol. Chem. 287, 514–522 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wu, Q. et al. Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. J. Clin. Invest. 131, e142865 (2021).

    Article 
    CAS 
    PubMed Central 

    Google Scholar
     

  • Lindell, G., Lunell, E. & Graffner, H. Transdermally administered nicotine accumulates in gastric juice. Eur. J. Clin. Pharmacol. 51, 315–318 (1996).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mu, Y. et al. Bacterial catabolism of nicotine: catabolic strains, pathways and modules. Environ. Res. 183, 109258 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gunasekaran, M. Direct evidence that sunbirds’ gut microbiota degrades floral nectar’s toxic alkaloids. Front. Microbiol. 12, 639808 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Agostoni, C. et al. Scientific opinion on the safety of ‘heat-treated milk products fermented with Bacteroides xylanisolvens DSM 23964’ as a novel food EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA J. 13, 3956 (2015).

  • Lavrynenko, O. et al. Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies. Life Sci. 263, 118753 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tippetts, T. S. et al. Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration. BMC Cardiovasc. Disord. 14, 165 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou, Y. J. et al. Screening for compensated advanced chronic liver disease using refined Baveno VI elastography cutoffs in Asian patients with nonalcoholic fatty liver disease. Aliment. Pharmacol. Ther. 54, 470–480 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kleiner, D. E. et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313–1321 (2005).

    Article 
    PubMed 

    Google Scholar
     

  • Lloyd-Jones, D. M. et al. Framingham risk score and prediction of lifetime risk for coronary heart disease. Am. J. Cardiol. 94, 20–24 (2004).

    Article 
    PubMed 

    Google Scholar
     

  • Hippisley-Cox, J., Coupland, C. & Brindle, P. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ 357, j2099 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl Acad. Sci. USA 110, 9066–9071 (2013).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu, Q. et al. Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis. Cell Metab. 33, 1988–2003 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114–2120 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Truong, D. T. et al. MetaPhlAn2 for enhanced metagenomic taxonomic profiling. Nat. Methods 12, 902–903 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Dhariwal, A. et al. MicrobiomeAnalyst: a web-based tool for comprehensive statistical, visual and meta-analysis of microbiome data. Nucleic Acids Res. 45, W180–W188 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Segata, N. et al. Metagenomic biomarker discovery and explanation. Genome Biol. 12, R60 (2011).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu, C. et al. Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank. Microbiome 9, 119 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Despres, J. et al. Unraveling the pectinolytic function of Bacteroides xylanisolvens using a RNA-seq approach and mutagenesis. BMC Genom. 17, 147 (2016).

    Article 

    Google Scholar
     

  • Apsunde, T. D. & Trudell, M. L. Microwave-assisted iridium-catalyzed synthesis of nicotine and anabasine derivatives. Synthesis 45, 2120–2124 (2013).

    Article 
    CAS 

    Google Scholar
     

  • Dye, F. S. et al. Characterisation of proguanylin expressing cells in the intestine evidence for constitutive luminal secretion. Sci. Rep. 9, 15574 (2019).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xuan, Q. H. et al. Development of a high coverage pseudotargeted lipidomics method based on ultra-high performance liquid chromatography-mass spectrometry. Anal. Chem. 90, 7608–7616 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ren, L. L. et al. TiO2 with tandem fractionation (TAFT): an approach for rapid, deep, reproducible, and high-throughput phosphoproteome analysis. J. Proteome Res. 17, 710–721 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu, P. et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature 508, 541–545 (2014).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Waterhouse, A. et al. SWISS-MODEL: homology modelling of protein structures and complexes. Nucleic Acids Res. 46, W296–W303 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

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