Nowbar, A. N., Gitto, M., Howard, J. P., Francis, D. P. & Al-Lamee, R. Mortality from ischemic heart disease. Circ. Cardiovasc. Qual. Outcomes 12, e005375 (2019).
Loffredo, F. & Lee, R. T. Therapeutic vasculogenesis. Circ. Res. 103, 128–130 (2008).
Melero-Martin, J. M. et al. Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ. Res. 103, 194–202 (2008).
Beckman, J. A., Schneider, P. A. & Conte, M. S. Advances in revascularization for peripheral artery disease: revascularization in PAD. Circ. Res. 128, 1885–1912 (2021).
Carmeliet, P. & Jain, R. K. Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298 (2011).
Cooke, J. P. & Losordo, D. W. Modulating the vascular response to limb ischemia. Circ. Res. 116, 1561–1578 (2015).
Wang, K., Lin, R.-Z. & Melero-Martin, J. M. Bioengineering human vascular networks: trends and directions in endothelial and perivascular cell sources. Cell. Mol. Life Sci. 76, 421–439 (2019).
Islam, M. N. et al. Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat. Med. 18, 759 (2012).
Hayakawa, K. et al. Transfer of mitochondria from astrocytes to neurons after stroke. Nature 535, 551 (2016).
Jain, R. K. Molecular regulation of vessel maturation. Nat. Med. 9, 685–693 (2003).
Andrae, J., Gallini, R. & Betsholtz, C. Role of platelet-derived growth factors in physiology and medicine. Gene Dev. 22, 1276–1312 (2008).
Rustom, A., Saffrich, R., Markovic, I., Walther, P. & Gerdes, H.-H. Nanotubular highways for intercellular organelle transport. Science 303, 1007–1010 (2004).
Zhang, Y. et al. iPSC-MSCs with high intrinsic MIRO1 and sensitivity to TNF-α yield efficacious mitochondrial transfer to rescue anthracycline-induced cardiomyopathy. Stem Cell Rep. 7, 749–763 (2016).
Hase, K. et al. M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Nat. Cell Biol. 11, 1427–1432 (2009).
Kitani, T., Kami, D., Matoba, S. & Gojo, S. Internalization of isolated functional mitochondria: involvement of macropinocytosis. J. Cell. Mol. Med. 18, 1694–1703 (2014).
Youle, R. J. & Narendra, D. P. Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12, 9–14 (2011).
Jin, S. M. & Youle, R. J. PINK1- and Parkin-mediated mitophagy at a glance. J. Cell Sci. 125, 795–799 (2012).
Liu, K. et al. Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer. Microvasc. Res. 92, 10–18 (2014).
Liang, X. et al. Direct administration of mesenchymal stem cell‐derived mitochondria improves cardiac function after infarction via ameliorating endothelial senescence. Bioeng. Transl. Med. 8, e10365 (2023).
Borcherding, N. et al. Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood. Cell Metab. 34, 1499–1513 (2022).
Kami, D. & Gojo, S. From cell entry to engraftment of exogenous mitochondria. Int. J. Mol. Sci. 21, 4995 (2020).
Elliott, R. L., Jiang, X. P. & Head, J. F. Mitochondria organelle transplantation: introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity. Breast Cancer Res. Treat. 136, 347–354 (2012).
Chang, J.-C. et al. Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson’s disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine–induced neurotoxicity. Transl. Res. 170, 40–56 (2016).
Kaza, A. K. et al. Myocardial rescue with autologous mitochondrial transplantation in a porcine model of ischemia/reperfusion. J. Thorac. Cardiovasc. Surg. 153, 934–943 (2017).
Emani, S. M., Piekarski, B. L., Harrild, D., Del Nido, P. J. & McCully, J. D. Autologous mitochondrial transplantation for dysfunction after ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg. 154, 286–289 (2017).
Bertero, E., Maack, C. & O’Rourke, B. Mitochondrial transplantation in humans: “magical” cure or cause for concern? J. Clin. Invest. 128, 5191–5194 (2018).
Lightowlers, R. N., Chrzanowska‐Lightowlers, Z. M. & Russell, O. M. Mitochondrial transplantation—a possible therapeutic for mitochondrial dysfunction? EMBO Rep. 21, e50964 (2020).
Ashrafi, G. & Schwarz, T. L. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 20, 31–42 (2013).
Moreau, K., Luo, S. & Rubinsztein, D. C. Cytoprotective roles for autophagy. Curr. Opin. Cell Biol. 22, 206–211 (2010).
Gao, Y. et al. Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury. J. Transl. Med. 18, 114 (2020).
Livingston, M. J. et al. Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys. Autophagy 15, 2142–2162 (2019).
Sun, Z. et al. MSC-derived extracellular vesicles activate mitophagy to alleviate renal ischemia/reperfusion injury via the miR-223-3p/NLRP3 axis. Stem Cells Int. 2022, 6852661 (2022).
Mahrouf-Yorgov, M. et al. Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties. Cell Death Differ. 24, 1224–1238 (2017).
Zhu, W. et al. Mesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy. Cell Death Dis. 9, 837 (2018).
Kim, M. J., Hwang, J. W., Yun, C.-K., Lee, Y. & Choi, Y.-S. Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function. Sci. Rep. 8, 3330 (2018).
Melero-Martin, J. M. et al. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood 109, 4761–4768 (2007).
Lin, R.-Z. et al. Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. Proc. Natl Acad. Sci. USA 111, 10137–10142 (2014).
More News
Could bird flu in cows lead to a human outbreak? Slow response worries scientists
US halts funding to controversial virus-hunting group: what researchers think
How high-fat diets feed breast cancer