Langley, J. N. The Autonomic Nervous System (W. Heffer & Sons, 1921).
Ernsberger, U. & Rohrer, H. Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies. Neural Dev. 13, 20 (2018).
Tao, J. et al. Highly selective brain-to-gut communication via genetically defined vagus neurons. Neuron 109, 2106–2115.e4 (2021).
Palma, J. A. & Benarroch, E. E. Neural control of the heart: recent concepts and clinical correlations. Neurology 83, 261–271 (2014).
Appel, M. L., Berger, R. D., Saul, J. P., Smith, J. M. & Cohen, R. J. Beat to beat variability in cardiovascular variables: noise or music? J. Am. Coll. Cardiol. 14, 1139–1148 (1989).
Gourine, A. V., Machhada, A., Trapp, S. & Spyer, K. M. Cardiac vagal preganglionic neurones: an update. Auton. Neurosci. 199, 24–28 (2016).
La Rovere, M. T., Bigger, J. T. Jr., Marcus, F. I., Mortara, A. & Schwartz, P. J. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet 351, 478–484 (1998).
Mortara, A. et al. Arterial baroreflex modulation of heart rate in chronic heart failure: clinical and hemodynamic correlates and prognostic implications. Circulation 96, 3450–3458 (1997).
Jouven, X. et al. Heart-rate profile during exercise as a predictor of sudden death. N. Engl. J. Med. 352, 1951–1958 (2005).
Panneton, W. M., Anch, A. M., Panneton, W. M. & Gan, Q. Parasympathetic preganglionic cardiac motoneurons labeled after voluntary diving. Front. Physiol. 5, 8 (2014).
Massari, V. J., Johnson, T. A., Llewellyn-Smith, I. J. & Gatti, P. J. Substance P nerve terminals synapse upon negative chronotropic vagal motoneurons. Brain Res. 660, 275–287 (1994).
Bennett, J. A., Kidd, C., Latif, A. B. & McWilliam, P. N. A horseradish peroxidase study of vagal motoneurones with axons in cardiac and pulmonary branches of the cat and dog. Q. J. Exp. Physiol. 66, 145–154 (1981).
Lee, B. H., Lynn, R. B., Lee, H. S., Miselis, R. R. & Altschuler, S. M. Calcitonin gene-related peptide in nucleus ambiguus motoneurons in rat: viscerotopic organization. J. Comp. Neurol. 320, 531–543 (1992).
Muller, D. et al. Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution. Science 343, 1264–1266 (2014).
Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168–176 (2007).
Cordes, S. P. Molecular genetics of cranial nerve development in mouse. Nat. Rev. Neurosci. 2, 611–623 (2001).
Rajendran, P. S. et al. Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Nat. Commun. 10, 1944 (2019).
Rajasethupathy, P. et al. Projections from neocortex mediate top-down control of memory retrieval. Nature 526, 653–659 (2015).
Hamlin, R. L. & Smith, C. R. Effects of vagal stimulation on S-A and A-V nodes. Am. J. Physiol. 215, 560–568 (1968).
Cheng, Z., Zhang, H., Yu, J., Wurster, R. D. & Gozal, D. Attenuation of baroreflex sensitivity after domoic acid lesion of the nucleus ambiguus of rats. J. Appl. Physiol. 96, 1137–1145 (2004).
Kaufmann, H., Norcliffe-Kaufmann, L. & Palma, J. A. Baroreflex dysfunction. N. Engl. J. Med. 382, 163–178 (2020).
Wehrwein, E. A. & Joyner, M. J. Regulation of blood pressure by the arterial baroreflex and autonomic nervous system. Handb. Clin. Neurol. 117, 89–102 (2013).
McAllen, R. M. & Spyer, K. M. The location of cardiac vagal preganglionic motoneurones in the medulla of the cat. J. Physiol. 258, 187–204 (1976).
Arrigo, M. & Huber, L. C. Eponyms in cardiopulmonary reflexes. Am. J. Cardiol. 112, 449–453 (2013).
Undem, B. J., Myers, A. C., Barthlow, H. & Weinreich, D. Vagal innervation of guinea pig bronchial smooth muscle. J. Appl. Physiol. 69, 1336–1346 (1990).
Haselton, J. R., Solomon, I. C., Motekaitis, A. M. & Kaufman, M. P. Bronchomotor vagal preganglionic cell bodies in the dog: an anatomic and functional study. J. Appl. Physiol. 73, 1122–1129 (1992).
Panneton, W. M. & Gan, Q. The mammalian diving response: inroads to its neural control. Front. Neurosci. 14, 524 (2020).
Mukhtar, M. R. & Patrick, J. M. Bronchoconstriction: a component of the ‘diving response’ in man. Eur. J. Appl. Physiol. Occup. Physiol. 53, 155–158 (1984).
Mazzone, S. B. & Canning, B. J. Evidence for differential reflex regulation of cholinergic and noncholinergic parasympathetic nerves innervating the airways. Am. J. Respir. Crit. Care Med. 165, 1076–1083 (2002).
Armelin, V. A. et al. The baroreflex in aquatic and amphibious teleosts: does terrestriality represent a significant driving force for the evolution of a more effective baroreflex in vertebrates? Comp. Biochem. Physiol. A 255, 110916 (2021).
Andersen, H. T. Physiological adaptations in diving vertebrates. Physiol. Rev. 46, 212–243 (1966).
Saternos, H. C. et al. Distribution and function of the muscarinic receptor subtypes in the cardiovascular system. Physiol. Genomics 50, 00062 (2018).
Lee, L. Y. & Pisarri, T. E. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir. Physiol. 125, 47–65 (2001).
Sturani, C., Sturani, A. & Tosi, I. Parasympathetic activity assessed by diving reflex and by airway response to methacholine in bronchial asthma and rhinitis. Respiration 48, 321–328 (1985).
Paxinos, G., Franklin, K. B. J. The Mouse Brain in Stereotaxic Coordinates Second Edition (Academic Press, 2001).
Daigle, T. L. et al. A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality. Cell 174, 465–480.e422 (2018).
Mani, B. K. et al. The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting. Mol. Metab. 6, 882–896 (2017).
Bieger, D. & Hopkins, D. A. Viscerotopic representation of the upper alimentary tract in the medulla oblongata in the rat: the nucleus ambiguus. J. Comp. Neurol. 262, 546–562 (1987).
Yackle, K. et al. Breathing control center neurons that promote arousal in mice. Science 355, 1411–1415 (2017).
Wang, X., Hayes, J. A., Picardo, M. C. & Del Negro, C. A. Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue. J. Physiol. 591, 2393–2401 (2013).
The Tabula Muris Consortium, Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562, 367–372 (2018).
Jiang, H., Lei, R., Ding, S. W. & Zhu, S. Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads. BMC Bioinformatics 15, 182 (2014).
Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15–21 (2013).
Fregoso, S. P. & Hoover, D. B. Development of cardiac parasympathetic neurons, glial cells, and regional cholinergic innervation of the mouse heart. Neuroscience 221, 28–36 (2012).
McGovern, T. K., Robichaud, A., Fereydoonzad, L., Schuessler, T. F. & Martin, J. G. Evaluation of respiratory system mechanics in mice using the forced oscillation technique. J. Vis. Exp. 75, e50172 (2013).
Tang, J. M. et al. Response gene to complement 32 maintains blood pressure homeostasis by regulating α-adrenergic receptor expression. Circ. Res. 123, 1080–1090 (2018).
Kovacs, K. J. Measurement of immediate-early gene activation—c-fos and beyond. J. Neuroendocrinol. 20, 665–672 (2008).
McAllen, R. M. & Spyer, K. M. Two types of vagal preganglionic motoneurones projecting to the heart and lungs. J. Physiol. 282, 353–364 (1978).
McCulloch, P. F. Training rats to voluntarily dive underwater: investigations of the mammalian diving response. J. Vis. Exp. 93, e52093 (2014).
Hult, E. M., Bingaman, M. J. & Swoap, S. J. A robust diving response in the laboratory mouse. J. Comp. Physiol. B 189, 685–692 (2019).
Desai, T. J., Brownfield, D. G. & Krasnow, M. A. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 507, 190–194 (2014).
Bron, R., Yin, L., Russo, D. & Furness, J. B. Expression of the ghrelin receptor gene in neurons of the medulla oblongata of the rat. J. Comp. Neurol. 521, 2680–2702 (2013).
Sherman, D., Worrell, J. W., Cui, Y. & Feldman, J. L. Optogenetic perturbation of preBotzinger complex inhibitory neurons modulates respiratory pattern. Nat. Neurosci. 18, 408–414 (2015).
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