Skaletsky, H. et al. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature...
Chromosomes
Stephens, P. J. et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144, 27–40...
Nature, Published online: 14 June 2023; doi:10.1038/d41586-023-01890-5Two studies now shed light on how chromosomes that undergo catastrophic shattering are transmitted...
Cell lines and reagentsAll of the cell lines were maintained at 37 °C under 5% CO2 and atmospheric oxygen. DLD-1, HeLa,...
Genome assembliesWe analysed the 47 T2T phased diploid de novo assemblies (94 haplotypes in total) produced by the HPRC4. We...
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution...
Our cells perform a marvel of engineering when it comes to packing information into small spaces. Every time a cell...
In most mammals, females have two X chromosomes and males have one X and one Y chromosome in each of...
Cell lines and cell cultureAll cell lines were cultured in DMEM supplemented with 10% fetal bovine serum (FBS) and penicillin–streptomycin...
Chromothripsis is a catastrophic mutational process that promotes tumorigenesis and causes congenital disease1–4. Chromothripsis originates from aberrations of nuclei called...