Department of Cellular and Molecular Medicine, Department of Bioengineering, Moores Cancer Center, University of California, San Diego, CA, USALudmil B....
mutational
Experimental methodsSample collectionAll enrolled patients were consented to an institutional biospecimen banking protocol and MSK-IMPACT29 testing, and all analyses were...
Generation and culture of human mammary epithelial cell linesThe wild-type human mammary epithelial cell line 184-hTERT L9 (SA039) and isogenic...
SamplesHuman blood mononuclear cells (MNCs) were obtained from four sources: (1) bone marrow, spleen and peripheral blood taken with written...
Nature, Published online: 13 April 2022; doi:10.1038/d41586-022-00976-wThroughout life, cells accrue mutations. It now emerges that longer-lived animals acquire mutations at...
Nature, Published online: 09 February 2022; doi:10.1038/d41586-022-00301-5Certain patterns of mutations occur frequently in cancer. The culprit behind one mutational signature...
1.Martincorena, I. & Campbell, P. J. Somatic mutation in cancer and normal cells. Science 349, 1483–1489 (2015).ADS CAS PubMed Article ...
Nature, Published online: 09 August 2021; doi:10.1038/s41586-021-03758-yAddendum: The mutational constraint spectrum quantified from variation in 141,456 humans Source link
New research from the University of Nebraska-Lincoln has shown that the mutations arising in the COVID-19-causing SARS-CoV-2 virus seem to...