Bhat, P., Honson, D. & Guttman, M. Nuclear compartmentalization as a mechanism of quantitative control of gene expression. Nat. Rev....
splicing
Cells treated with Senisca’s product (right) show reduced senescence (red) compared with untreated cells (left).Credit: Senisca Senisca in Exeter, UK,...
CloningRecombinant proteins were produced from codon-optimized synthetic genes (GeneArt, ThermoFisher Scientific). Full-length wild-type Aquarius and its K829A mutant were fused...
Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01528-6The processing of messenger RNA during splicing requires the activity of a complex of...
Patient samples and RNA-seq analysisRNA-seq data from 395 patients with PDA was obtained from the University Health Network (Toronto), Sunnybrook...
Wilkinson, M. E., Charenton, C. & Nagai, K. RNA splicing by the spliceosome. Annu. Rev. Biochem. 89, 359–388 (2020).CAS PubMed ...
AffiliationsRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USAAlex Mas Monteys, Amiel A....
In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate...
1.Yen, L. et al. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature 431, 471–476 (2004).ADS CAS ...
Human Usher syndrome (USH) is the most common form of hereditary deaf-blindness. Sufferers can be deaf from birth, suffer from...