Scheib, J. & Hoke, A. Advances in peripheral nerve regeneration. Nat. Rev. Neurol. 9, 668–676 (2013).
Ferguson, T. A. & Son, Y. J. Extrinsic and intrinsic determinants of nerve regeneration. J. Tissue Eng. 2, 2041731411418392 (2011).
Hutson, T. H. et al. Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models. Sci. Transl. Med. 11, eaaw2064 (2019).
Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M. & Cheng, A. Intermittent metabolic switching, neuroplasticity and brain health. Nat. Rev. Neurosci. 19, 63–80 (2018).
Longo, V. D. & Mattson, M. P. Fasting: molecular mechanisms and clinical applications. Cell Metab. 19, 181–192 (2014).
Asplund, M., Nilsson, M., Jacobsson, A. & von Holst, H. Incidence of traumatic peripheral nerve injuries and amputations in Sweden between 1998 and 2006. Neuroepidemiology 32, 217–228 (2009).
Evans, G. R. Peripheral nerve injury: a review and approach to tissue engineered constructs. Anat. Rec. 263, 396–404 (2001).
Taylor, C. A., Braza, D., Rice, J. B. & Dillingham, T. The incidence of peripheral nerve injury in extremity trauma. Am. J. Phys. Med. Rehabil. 87, 381–385 (2008).
Seddighi, A. et al. Peripheral nerve injury: a review article. Int. Clin. Neurosci. J. 3, 1–6 (2016).
Li, R. et al. Peripheral nerve injuries treatment: a systematic review. Cell Biochem. Biophys. 68, 449–454 (2014).
Lee, S. K. & Wolfe, S. W. Peripheral nerve injury and repair. J. Am. Acad. Orthop. Surg. 8, 243–252 (2000).
Mahar, M. & Cavalli, V. Intrinsic mechanisms of neuronal axon regeneration. Nat. Rev. Neurosci. 19, 323–337 (2018).
Lindborg, J. A. et al. Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury. J. Neuroinflammation 15, 192 (2018).
Strand, N. S. et al. Wnt/β-catenin signaling promotes regeneration after adult zebrafish spinal cord injury. Biochem. Biophys. Res. Commun. 477, 952–956 (2016).
Ghosh, S. & Hui, S. P. Axonal regeneration in zebrafish spinal cord. Regeneration 5, 43–60 (2018).
Shimizu, Y., Ueda, Y. & Ohshima, T. Wnt signaling regulates proliferation and differentiation of radial glia in regenerative processes after stab injury in the optic tectum of adult zebrafish. Glia 66, 1382–1394 (2018).
Chandran, V. et al. A systems-level analysis of the peripheral nerve intrinsic axonal growth program. Neuron 89, 956–970 (2016).
Fann, D. Y. et al. Intermittent fasting attenuates inflammasome activity in ischemic stroke. Exp. Neurol. 257, 114–119 (2014).
Fann, D. Y., Ng, G. Y., Poh, L. & Arumugam, T. V. Positive effects of intermittent fasting in ischemic stroke. Exp. Gerontol. 89, 93–102 (2017).
Jeong, M. A. et al. Intermittent fasting improves functional recovery after rat thoracic contusion spinal cord injury. J. Neurotrauma 28, 479–492 (2011).
Plunet, W. T. et al. Dietary restriction started after spinal cord injury improves functional recovery. Exp. Neurol. 213, 28–35 (2008).
Fontan-Lozano, A. et al. Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor. J. Neurosci. 27, 10185–10195 (2007).
Dasgupta, A., Kim, J., Manakkadan, A., Arumugam, T. V. & Sajikumar, S. Intermittent fasting promotes prolonged associative interactions during synaptic tagging/capture by altering the metaplastic properties of the CA1 hippocampal neurons. Neurobiol. Learn. Mem. 154, 70–77 (2017).
Lee, J., Seroogy, K. B. & Mattson, M. P. Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J. Neurochem. 80, 539–547 (2002).
Hervera, A. et al. Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Nat. Cell Biol. 20, 307–319 (2018).
Poplawski, G. et al. Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury.Glia 66, 1577–1590 (2018).
Lindsay, R. M. Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons. J. Neurosci. 8, 2394–2405 (1988).
Hollis, E. R.II, Jamshidi, P., Löw, K., Blesch, A. & Tuszynski, M. H. Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc. Natl Acad. Sci. USA 106, 7215–7220 (2009).
Liu, Y. et al. NT-3 promotes proprioceptive axon regeneration when combined with activation of the mTor intrinsic growth pathway but not with reduction of myelin extrinsic inhibitors. Exp. Neurol. 283, 73–84 (2016).
Boyd, J. G. & Gordon, T. Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol. Neurobiol. 27, 277–324 (2003).
Hoke, A. et al. Schwann cells express motor and sensory phenotypes that regulate axon regeneration. J. Neurosci. 26, 9646–9655 (2006).
Anson, R. M. et al. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc. Natl Acad. Sci. USA 100, 6216–6220 (2003).
Patterson, R. E. & Sears, D. D. Metabolic effects of intermittent fasting. Annu. Rev. Nutr. 37, 371–393 (2017).
Aragozzini, F., Ferrari, A., Pacini, N. & Gualandris, R. Indole-3-lactic acid as a tryptophan metabolite produced by Bifidobacterium spp. Appl. Environ. Microbiol. 38, 544–546 (1979).
Zhang, L. S. & Davies, S. S. Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions. Genome Med. 8, 46 (2016).
Dodd, D. et al. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature 551, 648–652 (2017).
Qiu, Z. et al. Pregnane X receptor regulates pathogen-induced inflammation and host defense against an intracellular bacterial infection through toll-like receptor 4. Sci. Rep. 6, 31936 (2016).
Venkatesh, M. et al. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity 41, 296–310 (2014).
Alexeev, E. E. et al. Microbiota-derived indole metabolites promote human and murine intestinal homeostasis through regulation of interleukin-10 receptor. Am. J. Pathol. 188, 1183–1194 (2018).
Hudson, G. et al. Pregnane X receptor activation triggers rapid ATP release in primed macrophages that mediates NLRP3 inflammasome activation. J. Pharmacol. Exp. Ther. 370, 44–53 (2019).
Wang, S. et al. Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells. J. Biol. Chem. 289, 30075–30081 (2014).
Biondo, C. et al. The interleukin-1β/CXCL1/2/neutrophil axis mediates host protection against group B streptococcal infection. Infect. Immun. 82, 4508–4517 (2014).
Dubrac, S., Elentner, A., Ebner, S., Horejs-Hoeck, J. & Schmuth, M. Modulation of T lymphocyte function by the pregnane X receptor. J. Immunol. 184, 2949–2957 (2010).
Schote, A. B., Turner, J. D., Schiltz, J. & Muller, C. P. Nuclear receptors in human immune cells: expression and correlations. Mol. Immunol. 44, 1436–1445 (2007).
Lindborg, J. A., Mack, M. & Zigmond, R. E. Neutrophils are critical for myelin removal in a peripheral nerve injury model of Wallerian degeneration. J. Neurosci. 37, 10258–10277 (2017).
Stirling, D. P., Liu, S., Kubes, P. & Yong, V. W. Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome. J. Neurosci. 29, 753–764 (2009).
Kurimoto, T. et al. Neutrophils express oncomodulin and promote optic nerve regeneration. J. Neurosci. 33, 14816–14824 (2013).
Sas, A. R. et al. A new neutrophil subset promotes CNS neuron survival and axon regeneration. Nat. Immunol. 21, 1496–1505 (2020).
Kigerl, K. A. et al. Gut dysbiosis impairs recovery after spinal cord injury. J. Exp. Med. 213, 2603–2620 (2016).
Staudinger, J. L. et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl Acad. Sci. USA 98, 3369–3374 (2001).
Li,M.,Fecal microbiota transplantation and bacterial consortium transplantation have comparable effects on the re-establishment of mucosal barrier function in mice with intestinal dysbiosis. Front. Microbiol. 6, 692 (2015).
Zhou, D. et al. Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota. Sci. Rep. 7, 1529 (2017).
Behrends, V., Tredwell, G. D. & Bundy, J. G. A software complement to AMDIS for processing GC-MS metabolomic data. Anal. Biochem. 415, 206–208 (2011).
Trygg, J. & Wold, S. Orthogonal projections to latent structures (O-PLS). J. Chemom. 16, 119–128 (2002).
Thévenot, E. A., Roux, A., Xu, Y., Ezan, E. & Junot, C. Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. J. Proteome Res. 14, 3322–3335 (2015).
Callahan, B. J. et al. DADA2: high-resolution sample inference from Illumina amplicon data. Nat. Methods 13, 581–583 (2016).
McMurdie, P. J. & Holmes, S. phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PLoS ONE 8, e61217 (2013).
McMurdie, P. J. & Holmes, S. Waste not, want not: why rarefying microbiome data is inadmissible. PLoS Comput. Biol. 10, e1003531 (2014).
Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).
Iwai, S. et al. Piphillin: improved prediction of metagenomic content by direct inference from human microbiomes. PLoS ONE 11, e0166104 (2016).
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