May 4, 2024
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis – Nature

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis – Nature

  • J.S.W., A.G.B. and S.J. conceived of the study and conceived of PACER. J.S.W. performed somatic variant calling, developed the PACER implementation and performed the human genetic association analyses. J.G. and S.J. functionally characterized the TCL1A locus. J.G. performed mouse model experiments. J.S.W. and S.J. performed WHI validation analyses. J.S.W., J.G., A.G.B. and S.J. wrote the manuscript with input from all authors. B.B.B., M.M.U., N.K., J.A.B., H.B., B.D., Z.M., N.L., T.M.M., S.E.L., K.P.P., S.R.M. and A.T.S. performed additional bioinformatic analyses. J.O.K., E.A.W. and A.P.R. contributed WHI amplicon sequencing data. C.A.L., J.G.B., K.D.T., X.G., M.F.S., A.S.V., S.K., A.R.S., J.R.O., J.P.L., E.B., K.C.B., N.C., E.E.K., R.J.L., M.F., L.H., D.M.L., S.R., B.E.C., B.M.P., J.C.B., J.A.B., E.K.S., J.H.Y., D.Q., N.D.P., B.I.F., D.W.B., M.H.C., D.L.D., V.S.R., L.R.Y., L.C.B., S.K., P.A.P., J.H., M.R., P.V.H., R.K., S.R.H., N.L.S., K.L.W., D.K.A., M.R.I., H.T., M.J.C., S.K., J.B.M., A.C., L.M.R., Y.G., M.A., J.I.R., S.S.R., R.P.T., B.A.K., J.M.J., M.M.W., J.G.S., O.M., P.M.N., B.S.C., R.D., J.E.C., J.B., S.M., L.K.W., S.X., M.Y., C.C.G., Y.I.C., W.L., G.M.M., J.P.K., C.R.P., M.B.S., D.D., D.R., C.A., C.K., Y.Z., J.E.M., P.K., A.D.J., R.A.M., T.W.B., G.R.A., A.V.S., H.M.K., P.N., E.A.W., A.P.R. and the NHLBI TOPMed Consortium contributed to sequencing and phenotyping of the included NHLBI TOPMed cohorts. T.W.B., G.R.A., A.V.S. and H.M.K. contributed TOPMed computing infrastructure and bioinformatics advice.

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