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Structural dataset and computational analysisThe experimentally determined 3D structure of the CD45 extracellular domain was retrieved from the PDB (5FMV)22....
haematopoiesis
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USAWaihay J. Wong, Abhishek Niroula, Christopher J. Gibson, Veronica Kovalcik, Amy E. Lin, Marie E. McConkey, Rob...
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Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USAJoshua S. Weinstock, Gonçalo...
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Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USAWaihay J. Wong, Abhishek Niroula, Christopher J. Gibson, Veronica Kovalcik, Amy E. Lin, Marie E. McConkey, Rob...
A full list of members and their affiliations appears in the Supplementary InformationRegeneron Genetics Center, Tarrytown, NY, USAMichael D. Kessler, Amy...
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de Laat, W. & Duboule, D. Topology of mammalian developmental enhancers and their regulatory landscapes. Nature 502, 499–506 (2013).Article ADS ...
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Study approvalUKB study: ethical approval for the UKB study was previously obtained from the North West Centre for Research Ethics...
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Study participantsEthical permission for this study was granted by The East of England (Essex) Research Ethics Committee (REC reference 15/EE/0327)....
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SamplesIn order to obtain representative data from across the whole human lifespan, samples were obtained from three sources: (1) Stem...