N.F.L. Week 1 Predictions: Our Picks Against the Spread

Seattle Seahawks at Indianapolis Colts, 1 p.m., Fox

Line: Seahawks -2.5| Total: 49.5

The Colts hoped new scenery would resurrect the 2017 version of Carson Wentz, who helped lead the Eagles in the regular season on a run to a title, but a foot injury and a stint on the Covid list robbed him of valuable training camp reps with his new teammates. He’ll face a Seahawks defense that surrendered the second-most passing yards in the league to opposing teams last season but that hopes linebacker Bobby Wagner and safety Jamal Adams can turn the unit into a more consistent threat. (Adams’s 9.5 sacks last season were the most ever by a defensive back.)

Seattle will lure opponents into trying to keep up with the scoring pace of Russell Wilson, D.K. Metcalf and Tyler Lockett, as it did last year. Wentz will be the first to find out how much tougher that has become. Pick: Seahawks -2.5

Sunday’s Other Games

Los Angeles Chargers at Washington Footballers, 1 p.m., CBS

Line: Chargers -1| Total: 44.5

Oddsmakers predict this will be a tossup because the Chargers enter this season as an unknown under their new coach, Brandon Staley. On paper, the team should improve with quarterback Justin Herbert, the reigning Offensive Rookie of the Year Award winner; a remodeled offensive line; and the return of safety Derwin James. But it may take time for the team to fully grasp Staley’s system and for the offensive line to jell. Blocking Washington’s pass rush, led by Chase Young, last season’s Defensive Rookie of the Year Award winner, is a tough first task. Pick: Washington +1

Philadelphia Eagles at Atlanta Falcons, 1 p.m., Fox

Line: Falcons -3.5 | Total: 48

The Eagles placed their faith in Jalen Hurts when they traded Carson Wentz to the Colts, and selected his former Alabama teammate DeVonta Smith in the first round of the draft to boost a receiving corps often criticized for its lack of production. They’ll relish going up against a Falcons defense that allowed the most passing yards in the league last season.

Atlanta focused on improving its offense in the draft, selecting tight end Kyle Pitts with the No. 4 overall pick, and it’s possible that could carry the Falcons in this game. But it is also possible that Philadelphia can upset a team that is somewhere between rebuilding and contending. Pick: Eagles +3.5